![]() ![]() ![]() Research suggests that DIM preferentially promotes the metabolism of estrogen to the less harmful, and less active 2-hydroxyestrone form. This endogenous estrogen can either be metabolized to 16alpha-hydroxyestrone (16OHE1) or 2-hydroxyestrone (2OHE1). Further research is required to confirm these results before attributing all of the beneficial effects of I3C to DIM.īoth males and females produce estrogen naturally in their bodies, although women produce significantly higher levels. Recent research has implied that benefits previously attributed to I3C may actually be the result of DIM created through conversion in the digestive tract. This chemical is more shelf-stable and more easily absorbed in the digestive tract than I3C. Part of this effect is likely due to DIM's role in estrogen metabolism balance in the body (see below).There is also preliminary research implicating DIM as an immunomodulating supplement against auto-immune disease, although further research is required.ĭIM is a natural diindole condensation product of I3C created during digestion in the presence of sufficient stomach acid. By: Articles by a Naturopathic Doctor ( N.D.)ĭiindolylmethane (DIM) is a natural condensation product of indole-3-carbinol (I3C), which is found in cruciferous (Brassica family) vegetables such as cauliflower, cabbage, cress, bok choy, broccoli, kale, and similar green leaf vegetables. ![]()
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